This special leaf can be found around us- in our neighborhood. Differences between means were considered to be significant at (p<0.05) using LSD (Least Square Difference) post hoc test. In these groups, from mild to severe order; shows observable congested portal vein, the liver parenchyma showed area of harmorrhage, the morphology of the hepatocytes appear pyknotic, some show mild fat infiltration (red arrow) the sinusoids appear fibrotic with infiltration of inflammatory red cells (red arrow). Paes-Leme AA, Motta ES, De Mattos JCP. Elevated activity of catalase in liver and kidney across tested doses of J. carnea ethanol extract showed no significant effect compared to the control. Oral acute toxicity study on J. carnea ethanol extract (JCEE) was carried out according to Lorke [15] method using the total of twelve (12) albino rats in two phases. Arch Toxicol. The levels of white blood cell count, lymphocyte, granulocyte and MID could indicate that ethanol extract of J. carnea leaf pose no toxicity or sub acute inflammation to the overall defense mechanism and immunity of the experimental rats. Catalase activity (U/ml) was measured following the method of Sinha [17]. 2011;5(9):48992 https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867. Mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) showed significant (p<0.05) increased at 50mg/kg while doses greater than 100mg/kg showed no significant difference compared to the control. Mr. E.S. Olaniyan JM, Hadiza LM, Hussaini AM, Musa BB, Abubakar SA. Great for use as a foundation or mass planting, it is also terrific for containers or as a houseplant. Cookies, This site is protected by reCAPTCHA and the Google, Justicia scheidweileri (Purple Shrimp Plant), Justicia americana (American Water-Willow), Want Garden Inspiration? J. Pharmacogn. J Ethnopharmacol 1999;64(3):265-270. Microsomal lipid peroxidation. As declared by all authors, no competing interests exist. Sun M, Zigma S. An improved spectrophotometer assay of superoxide dismutase based on epinephrine autoxidation. J Ethnopharmacol. View abstract. These animals were obtained from the animal house of the Department of Chemical Sciences, Ladoke Akintola University of Technology Ogbomoso Oyo State, Nigeria. It is believed by local consumers in Ghana to possess anti-anaemic effects that boost blood levels in pregnant women, anaemic patients and also . Star Apple: Amazing Health Benefits of eating its fruits. 2005 - 2023 WebMD LLC, an Internet Brands company. Justicia carnea is affects Fertility according to a researched article published on ResearchgateJusticia carnea was found to lower sperm count Male Wistar Albino ratsthe effect of this herb on female fertility is not yet known. leaf inhibits interferon-γ secretion and has bacteriostatic activity against Acinetobacter baumannii and Klebsiella pneumoniae. The animals were allowed free access to rat chow and water ad libitum. 1. While every effort has been made to describe these plants accurately, please keep in mind that height, bloom time, and color may differ in various climates. The plant, which is usually green in color and produces pink flowers, belongs to the family of Acanthaceae. One of the side-effects of some orthodox drugs used in the past had been excessive inhibition of the carbohydrate-hydrolyzing enzymes, which in turn leads to abdominal discomfort and. Ewe eje isnt capable of causing any side or negative effects if consumed moderately. Blooming from early summer to fall, the flowers are attractive to hummingbirds and butterflies. 2012;9(1):817 https://doi.org/10.4314/ajtcam.v9i1.12. Justicia carnea is a medicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. The minerals present in justicia carnea (Ewe eje or ogwu obara) are calcium, iron, magnesium, copper and zinc. The principle is based on the reduction of dichromate in a weak acid medium (acetic acid) to chromic acetate which is further heated in the presence of hydrogen peroxide to form an unstable intermediate (perchromic acid) that can be monitored spectrophotometrically at 620nm. Uses, Benefits, Cures, Side Effects, Nutrients in Justicia Betonica. But like in the case of depression and hepatitis, other species of justicia have been studied and proven to be antiepileptic. Pot the specimen and bring it indoors to add a bright touch of color to your interiors. They should be watered regularly (once per week), but not overwatered. The leaves of justicia carnea possess high content of iron and vitamin C. This compounds may be responsible for the blood boosting property of ewe eje leaves. Kone WM, Koffi AG, Bomisso EL, Tra Bi FH. Technical guidelines assembly of veterinary medicine research. Emmanuel Sina Akintimehin. Prof. F.O. From mild to severe order, the graded doses showed distorted renal cortex with collapsed renal glomeruli and dillated capsular spaces. The species Justicia secunda Vahl belongs to the family - Acanthaceae - together with up to 600 other shrubs and herbs species. Biochem Pharmacol. Joseph, H., Gleye, J., Moulis, C., Fouraste, I., and Stanislas, E. O-Methoxylated C-glycosylflavones from Justicia pectoralis. Clin Phytosci 7, 2 (2021). The major use of Justicia carnea leaves is to improve blood production. The animals were initially examined for any signs of toxicity after 60min of administration and further observed for a period of 24h. The absence of rat mortality in phase I necessitated the conduct of the second phase. The ameliorative effect of Justicia carnea on blood glucose level and lipid profile in alloxan-induced diabetic albino rats was evaluated in a study titled, "Effects of methanol leaves extract . The effect of the ethanol extract of Justicea. The liver and kidneys were excised and rinsed immediately in a normal saline (0.9% Nacl) to remove blood stain, dried between layers of Whatman filter paper, weighed and homogenized to obtain the supernatant for biochemical analysis. SOD activity was determined by its ability to inhibit the auto-oxidation of epinephrine determined by the increase in absorbance at 480nm. Ewe eje is an age-old herb medically proven to act as a blood tonic which can be attributed to its nutritional composition. Note: A=change in absorbance, TV=total volume, SV=sample volume, =molar extinction=4020M1cm1, TP=total protein. International Journal of Biochemistry Research & Review. J. Appl. 3. Justicia Carnea leaves extract contains a rich supply of iron, riboflavin, vitamins A, C, E, B1, B2, B9, and B12. Adetuyi is a Professor of Biochemistry in the Department of Chemical Sciences, Faculty of Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. The appropriate dose of Justicia pectoralis depends on several factors such as the user's age, health, and several other conditions. Authors TSO, KOK and ESA manage experimental protocols and performed the experiments under the supervision of FOA. The hematopoietic systems represent a sensitive target of toxic compounds and an essential index of physiological and pathological status in experimental animals [24]. Hepatic and renal damage has been recently linked with the use of medicinal plants in the treatment of various diseases [5, 6]. Becoming a contributing member of Gardenia is easy and can be done in just a few minutes. In sub-acute toxicity study, total of thirty (30) rats were randomized into six groups of five rats per group: Group 1 served as control and was administered with 1ml of distilled water (dH2O). We currently have no information for JUSTICIA PECTORALIS overview. The renal tubules and interstitial spaces appears distorted with presence of red inflammatory cells infiltrating the renal interstitial spaces as well as focal sclerosis of renal glomeruli with associated degeration of the glomerular membrane. Manage cookies/Do not sell my data we use in the preference centre. Studies on the Phytochemical and Nutritional Composition of Aqueous Leaf Extract of Justicia Carnea and its Effect on Some Biochemical Parameters in Anaemic Rats. Justicia carnea is a popular ornamental plant, which possesses powerful medicinal values. The spectacular rosy plumes of the flamingo-colored flower are distinctive and attract hummingbirds to pollinator gardens. Photomicrograph of liver sections stained with haematoxylin and eosin (H & E) are presented in Fig. Article They range in colors such as red, orange, mauve, magenta, apricot, and pink. Ogbe RJ, Adoga GI, Abu AH. 2008;108(9):14807. This plant is somewhat drought-tolerant once established but looks best with regular watering during periods of extended dry weather. This is due to the inability of the pancreatic beta cells to secrete insulin, which transports glucose to cells, or the inability of cells of the body to recognize insulin. The resultant liquid would turn crimson red. aqueous extract J. carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male Wistar albino rats. Privacy Note: A=change in absorbance, TV=total volume, SV=sample volume, TP=total protein, =molar extinction =1.34104M1 cm1. 10.17306/J.AFS.2017.0492. Daily intake of the Ewe eje or ajeri can increase the absorption of iron and vitamins, Uses and health benefits of Ewe eje (Justicia carnea leaf). Different drugs are used but many depend mainly on plants and herbal products for its treatment. [1] The perennial plant is native to the Atlantic Forest ecoregions of eastern Brazil . PubMed A cup of water Article Control treatment showed normal central venules without congestion, the morphology of the hepatocytes appear normal, the sinusoids appear normal with no observable form of infiltration and no observable pathological lesion seen. One of the numerous nutritional benefits of justicia carnea leaves is in the possession of various forms of the B vitamins such as Vitamin B1, B2, B6, B9, and B12. Relative to control, lymphocyte and granulocyte exhibited no significant difference in all doses while MID was elevated in treated groups with significant increase in rats administered with 500 and 800mg/kg body weight. Ashwagandha tea: 10 benefits, side effects and recipes, 7 interesting health facts about Black sapote fruits. The indistinguishable differences of total protein in the liver and kidney of rats treated with ethanol extract of J. carnea could indicate that the plant extract did not alter protein synthetic function of the organs. The Pros and Cons of Creatine You Should Know. Ewe eje as it is fondly called by the Westerners in Nigeria is a plant known for its blood boosting abilities. Rats were routinely observed for signs of toxicity. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. 1. Justicia carnea [jus-TEE-see-ah, KAR-nee-uh] is popularly known as the Brazilian Plume Flower. Where, A=absorbance, TV=total volume, SV=sample volume, =extinction coefficient, TP=total protein. In a study conducted by Onyeabor and colleagues, the leaf extract of jusiticia carnea reverses the anemic effect of phenylhydrazine on the pack cell volume, red blood cell, and hemoglobin concentrations. Materials and Methods Although, medically, it is advised you see your doctor or a physician before using the leaf for medicinal uses. Springer Nature. Acta Sci Pol Technol Aliment. A total number of forty two (42) male albino rats weighing between 120 and 170g were used in this study. Keep the soil moist, but not waterlogged. Studies have also confirmed this claim. OTHER NAME(S): Achille Millefeuille, Achille Mille-Feuille, Ana. 2003;66:1499503. https://doi.org/10.1016/j.jep.2007.02.011. Afr J Tradit Complement Altern Med. Fertility leaves: Benefits and side effects, Guava Leaf Tea: Health Benefits of Guava Leaves, Coriander seeds: 18 benefits Coriandrum sativum fruits and seeds, Rapini: Nutritional facts, benefits, side effects and care. Tietz NW. Omogunwa is a graduate of Biochemistry from the Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. 1978;90:819. Keep in mind that natural products are not always necessarily safe and dosages can be important. PubMed Central Canadian J Appl Sci. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. The effect of the ethanol extract of Justicea carnea (JC) leaves in phenylhydrazine induced-anemia albino rats on haematological and lipid profile parameters was investigated. When it comes to blood boosting and treatment of anemia, justicia carnea has proven beyond doubt to be an effective remedy. Ewe eje can also be used to manage abnormalities associated with anaemia and for the treatment and management of diabetics. W Afr J Biol Sci. 16. Lipid peroxidation was determined by measuring the formation of thiobarbituric acid reactive substances (TBARS) according to the method described by Buege and Aust [20]. Diallo A, Gbeassor M, Vovor A, Eklu-Gadegbeku K, Aklikokou K, Agbonon A. Justicia carnea (belonging to Acanthaceae family) is a flowering plant consisting ~600 species that are widely distributed in the tropics and subtropics [7]. long (25 cm), and showy flower plumes, 8 in. You can add milk or honey for taste before drinking. As reported by science, Justicia carnea is composed of secondary metabolites such as: flavonoids, terpenoids, alkaloids, phenols, saponins and tannins. Stover PJ, Caudill MA. The leaves were able to greatly lower the total cholesterol, LDL-cholesterol, and triglyceride levels, but increased the serum level of high density lipoprotein (HDL) cholesterol. J Ethnopharmacol. Control treated group showed normal micromorphological sections. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. It may be, judging from the antidepressant activity of other plant of justicia species whose activity have been studied, proper to state that justicia carnea may possess antidepressant properties. The plant has various other common names including: Back in the day, the Justicia flower was boiled and used to solve anemia problems. I am a practicing medical doctor, a philosopher, critical thinker, a globalist, a patriot, SEO expert and a patient blogger. Saunders; 1995. p. 26873. Justicia carnea is commonly cultivated and grown as an ornamental potted plant. Create a membership account to save your garden designs and to view them on any device. No observable focal sclerosis of renal glomeruli, capsular spaces around the glomerulus appears normal with distinct layering of renal microcellular structures. Estimation of total, protein-bound, and non-protein sulfhydryl groups in tissues with Ellmans reagent. Make sure to follow the package instructions carefully. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Histopathological examinations of sections of the liver collected from the 4 Summer temperatures above 77 degrees Fahrenheit (25 C) are perfect. Ewe eje is a rich source of phytochemicals, minerals and vitamins. View abstract. It is not. Accept The results of this study suggests that ethanol extract of J. carnea leaf is relatively safe, could be beneficial in alleviating hematology related abnormalities without causing adverse effects on endogenous antioxidant system. When properly boiled in water, the aqueous leaf extract turns red, and when mixed with milk turns pink. Article Lorke D. A new approach to practical acute toxicity testing. degree in Biochemistry fromUniversity of Ado-Ekiti, Ekiti State, Nigeria and University of Ibadan, Nigeriarespectively. There should be further studies on the antidepressant activity of justicia carnea leaves. 1.3.1 Aetiologyof Anaemia Anaemia may be due to a single factor such as a nutritional deficiency or multifactorial (McEvoy, 2013). Join now and start creating your dream garden! The red coloration of the decoction made people think that the plant must contain blood boosting compounds. Article ID 687197, 2013; p. 13. https://doi.org/10.1155/2013/687197. Aside boosting blood production in normal persons, justicia carnea leaves also reverses anemic conditions. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Different drugs are used but many depend mainly on plants and herbal products for its treatment. Anaemia is a common blood disorder that affects people of all ages, though people at greater risk are the elderly, young women and infants. Read also (Cashew leaves: health benefits and side effects of Anacardium occidentale). In this article i will take you through the nutritional and medicinal benefits of justicia carnea. This requires more attention to properly document the various health benefits of justicia carnea. These antibodies help prevent infections and fight off diseases. The cuttings are taken from the parent plant in the spring after the plant has bloomed. https://doi.org/10.35841/biomedicalresearch.30-18-666. In phase I, rats were randomized into 3 groups of 3 rats per group. Proximate analysis of the aqueous extract of J. carnea leaves showed that it contains appreciable amounts of 53.07 0.07% carbohydrate, 9.26 0.02% ash, and 26.71 0.02% . In the kidney, SOD and MDA level were indistinguishable compared to the control except SOD level in rats that received 800mg/kg JCEE that reduced significantly (p<0.05). The authors acknowledge the Director and staff of Peak Health Diagnostic and Research Laboratory, Ibadan, Oyo State, Nigeria, for the technical support and interpretation of the histology. -Amylase binding-interaction with JCAE was also investigated using fluorescence spectroscopy and molecular docking. Justicia carnea is amedicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. View abstract. CAS Powdered sample (1000g) was soaked in absolute ethanol (3000mL) with constant stirring. Regular intake can reduce your risk of liver diseases like liver cirrhosis, hepatitis and liver inflammation. It is nicknamed the Blood leaf, Blood of Jesus, and Jehovah Witness leaf in Nigeria, and is a widely used leaf across states in Nigeria. It is also known as Jacobinia carnea, and is a part of the Acanthaceae family along with the Aphelandra squarrosa (Zebra plant) and Crossandra. Tropical habitats mean constant moisture. 2023 BioMed Central Ltd unless otherwise stated. Olumese FE, Onoagbe IO, Eze GI, Omoruyi FO. Inhibitory Potential and Antidiabetic Activity of Leaf Extracts of Justicia carnea. However, serious caution of the dose should be taken into consideration when extrapolating this result for human consumption. Clinical Guide to Laboratory tests. However, there have not been scientific backing on this claim, yet, from the antiviral properties of other species of justicia, it could be that this plant possess antiviral properties which is utilized in the treatment of hepatitis infection. Safety assessment of oral administration of ethanol extract of, $$ \mathrm{Total}\ \mathrm{protein}\kern0.5em =\kern0.5em \frac{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{sample}}{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{standard}}\kern0.5em \times \kern0.5em \mathrm{Concentration}\ \mathrm{of}\ \mathrm{standard} $$, $$ \mathrm{Catalase}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}\right)=\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{SOD}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}/\mathrm{mg}\ \mathrm{protein}\right)\kern0.5em =\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{Concentration}\kern0.5em \mathrm{of}\kern0.5em \mathrm{reduced}\kern0.5em \mathrm{GSH}\kern0.5em =\kern0.5em \frac{\left(\Delta \mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\left(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}\right)} $$, $$ \mathrm{Malondialdehyde}\kern0.5em =\kern0.5em \frac{\left(\mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\Big(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, https://doi.org/10.1186/s40816-020-00234-4, https://doi.org/10.1016/j.jep.2015.06.005, https://doi.org/10.1016/j.joad.2015.08.006, https://doi.org/10.1016/j.jep.2005.06.013, https://doi.org/10.3109/08860220903367585, https://doi.org/10.1590/S0102-695X2011005000196, https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867, https://doi.org/10.35841/biomedicalresearch.30-18-666, https://doi.org/10.1016/j.jep.2007.02.011, https://doi.org/10.1186/s40816-019-0104-4, https://doi.org/10.1016/j.fitote.2008.02.005, https://doi.org/10.1016/j.jada.2008.06.430, https://doi.org/10.1016/j.biocel.2006.07.001, https://doi.org/10.1186/s12906-015-0760-y, http://creativecommons.org/licenses/by/4.0/. Several medicinal plants such as Xylopia aethiopica [25], Tectona grandis [26] and extracts of M. indica, A. hybridus and T. occidentalis [27] have also been reported to elevate RBC, hemoglobin and packed cell volume. Inflammation is a complex biological response of body's tissue to harmful stimuli like infections, toxins and itself. Decreased white blood cell count was obtained in this report, the level of lymphocyte and granulocyte was not altered by the extract while MID sized cell was significantly elevated at 500 and 800mg/kg dose. Inter J Biochem Cell Bio. The liver histopathological examination of the groups treated with J. carnea ethanol extract (JCEE) leaf showed normal liver architecture with slight abnormalities (such as mild fat congestion and hemorrhage) in the central venules of groups that received high doses. I also conduct research on molecular basis of human diseases, linking the pharmacological properties of certain natural products and their mechanisms of actions to the treatment of such diseases. 2013;1:38898. These compounds beyond boosting your blood concentration, thereby enhancing the transport of nutrients to various parts of the body, also boost your immune system against several infectious diseases. There are several scientific studies which show that the methanolic leaf extract of Justicia carnea protects the liver from toxic effect of carbon tetrachloride harmful effect on the live integrity and functions. Karigidi is a lecturer in the Biochemistry unit of Chemical Sciences Department, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. All authors read and approved the final draft of the manuscript. Photomicrograph of a liver sections stained with Haematoxylin and Eosin (Mag. Liver and kidney are the main targets of toxicants because they are respectively involved in biotransformation and excretion of xenobiotics. In phase two, three rats were separated into 3 groups of one rat per group. Clin Phytosci 2019; 5:9. https://doi.org/10.1186/s40816-019-0104-4. hindawi publishing corporation evidence-based complementary and alternative medicine. Contamination of medicinal plant could be as a result of contaminants (such as heavy metals, aflatoxin and pathogenic microbes) from soil and manner of herbal preparations [4]. Nunes TRS, Cordeiro MF, Beserra FG, et al.
