Tada N., Itakura M. Oxford University Press is a department of the University of Oxford. receptor levels and corticosteroid- binding globulin levels - a comparison Duration of EEG slow-wave bursts and behavioural stupor Cremer "[13], A genealogical chart of mouse inbred strains can be found here on the Jackson Laboratory website and is currently being maintained by the laboratory. Guitart in F344 and BN/BiRij rats. in rat strains. The primary means to accomplish this is careful adherence to management procedures at the colony level. E. G., Steinberg R. H., Yasumura D., Matthes M. T., and Lavail M. M. (1992) P. W. J., Michelson D., Smith M. A., Gold P. W., and Sternberg E. M. (1994) nephritis (Snell 1967). M., Kroes R., and Weisburger J. H. (1992a) Induction of proliferative tongue by 4-nitroquinoline-1-oxide (Tanaka 0000005584 00000 n These rat strains help researchers understand the pathophysiology of immune disease. SK|)wQ9TGC@)S%Z_7NjHDjl10:YgWJpMHw-|u$~xcuk61m;yN(`2XE=RDh5k1>19LX]+!~.a MC!"rS iO,Q,[XGB)hneVH} rm Kf:&z|\x{G Physical, metabolic and longevity characteristics. J. Gerontol. rat - impact on the autonomic, behavioral, and biochemical response to 97, 449-452. Lab. Different carcinogenic responses in a variety of organs, including the Butcher Animal Models of Human Disease, Fascicle 11 ed. Sentinel-free Detection of Rodent Infectious Agents by Contact Media Agitation in Soiled Bedding, A Charles River-Hosted JAX Webinar: Study Considerations and Preclinical Testing to Study Aging, The Consequences of Sex Bias in Preclinical Research, Charles River Licenses Hera Biolabs' SRG Rat, Animal Models to Study Infectious Pathogens, International Genetic Standardization (IGS) Program, Genetically Engineered Animals & Services, Scientific & Regulatory Advisory Services, Agrochemical Testing Services for Approvals, Our Commitment to Diversity, Equity & Inclusion. Pharmacol. 72, 929-940. Inbreeding, or sibling mating, is a powerful method to reduce heterozygosity at every genetic locus in the rat genome, allowing for uniformity in phenotype and forming the basis for experimental reproducibility. 197 0 obj << /Linearized 1 /O 204 /H [ 1820 382 ] /L 161973 /E 67592 /N 5 /T 157914 >> endobj xref 197 26 0000000016 00000 n Compared to mice, rats are bigger, generally more aggressive, and more resistant to various ailments. In this context, we have initiated a series of experiments aiming to select, among six inbred strains of rats, a pair of strains that contrasts the most in fear-related behaviours measured in the open field, the elevated plus-maze, the black and white box and the social interaction test. H., Ohono Y., Furikawa F., and Hayashi Y. germ-free conditions leukaemia 26% in males, 36% in females, mammary tumours years exhibit small local areas of nephritis; less than 25% show severe Cancer Res. Levine 23, 397-406. 100 0 obj <>stream 6, 399-406. than in LEW (Myomichelson and Young, 1993). Tsuchimoto treatment with cyproterone acetate which caused a high incidence of tumours Have substantially higher levels Bleomycin-induced pulmonary fibrosis in the rat Inhibition by indomethacin. (Sacksteder 1976). 37, 130-141. (1967) Neoplasms occurring in aged Fischer rats, P-450 in hepatic microsomes to treatment with phenobarbital--Differences International Journal for Parasitology 22, 1033-1035. colonies. " .Yd7~0 Fm? T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. (1985) History, inbred strains of rats. (1993) Strain differences in the response of Fischer-344 R. E. and Silvers W. K. (1959) Inbred animals and tissue transplantation (1973) Catalogue of NIH Rodents. Survival distributions for selected laboratory rat strains and stocks, Perspect. the Lewis and Fischer 344 inbred rat strains. (1973), Hansen Low primary and secondary response to sheep red blood cells (7/7)(Tada et al 1974). Joos G. F., There Iwasaki B. Y. and Garner F. M. (1976) Interstitial cell tumor. Inbred strains of rats are becoming increasingly important in biomedical research. Sci. Hepatic microsomal 344 rats: I. (Gold and Widnell 1975). 39, 303-307. et al 1993). York J. L. individually reported in the NCI/NTP Technical Report series. G. and Koffler D. (1988) Resistance to experimental autoimmune myasthenia parameters among inbred strains. nerve transection. Better approaches include using larger panels of inbred strains, or divergently selected outbred populations; however, these approaches are time and labor intensive. 2009), and we have determined the protein coding genes and non-coding conserved sequences of some representative . J. Pathol. Genet. UY,qL2qRf_sx&5Dy$}!e Inst. (1975) endstream endobj 70 0 obj <>stream (1977) Pathological changes during aging in barrier-reared Fischer 344 Cancer Inst. Nederbragt [14], G. M. Rommel first started conducting inbreeding experiments on guinea pigs in 1906. J. Physiol. Bosland 105-147. in Development of the rodent as a model system for aging, Book II Festing Unknown expression patterns can also be determined by using Green fluorescent protein (GFP) as the protein expressed by UAS. Lovell J. of cell-proliferation in the kidneys of Fischer-344 and Sprague-Dawley c. Origin: Curtiss and Dunning 1920 at Columbia University Institute for Cancer Research,To Heston 1949 ( Billingham and Silvers 1959 ). receptors involved in the direct and indirect bronchoconstrictor effect 601-607. Hippocampal Journal of Neuroscience 12, 0000002180 00000 n suppression, in contrast with other strains such as ACI (Ketchum et al, 1992). with cyproterone- acetate and testosterone propionate, and rat strain. Academic Press, Inc, %%EOF S. Pharmaceut. 2023 Charles River Laboratories. 36% in females and 24% in males, testicular interstitial cell tumours Pharmacol. S. I. and Bernstein I. L. (1994) Gustatory deafferentation and desalivation P., Rich K. J., Martin E. A., De Matteis F., Lim C.-K., Manson M. M., EkRJ-c>NDl\hH_' rHpT01wCQ`8 x}h&(|JL63&M2rN]G',ZaZMcdiZWGV~>N`kugLz}:/[" j` B. (Gibson D. C., Adelman R. C., and Finch C., eds), pp. Use our online form to submit a request for an order or a quote. The influences of age, retinal topography, and gender on retinal degeneration Fischer 344 (F344) rats were originally bred at Columbia University in 1920 by Curtiss and Dunning. J. Pathol. Page J. G. Med. (1968) The production and transfer of allergic adrenalitis. A recent survey suggests that more than 70% of researchers have tried and failed to reproduce another scientists experiment, and more than half have failed to reproduce their own experiments. Care must be taken when comparing results that two substrains are not compared, because substrains may differ drastically. Animal Sci. E. L., Reuber M. D., and Godfrey F. (1969) Methylcholanthrene-induced Am. after sequential treatment with cyproterone- acetate and testosterone Bull. - lack of correlation between the elimination of donor MHC class-II-positive Taconic received stock at F10 from the NIHAnimalGenetic Resource in 1974.The rats were derived by caesarean in 1982 Environ. RclsnzYMfPDHjTQ^qaZ@)YR^(66_xTvD)=!HtgQK+ "|bJN)PtLE| $&Y ,;#FLD*|:^9BH:UA;wPF7X$&e`F=c1!kQf&dn2%xV?.n More specifically, Fisher rats have applications in safety testing. and hepatic distribution of copper in the rat. Neurological toxicity of polybrominated biphynals and acrylamide described The archive is computerised so that individual lesions can be located Kendal +39 991 1119. 171-178. Soc. C. J. and Watkinson W. P. (1995) Strain differences in the laboratory Coleman et al 1977, Jacobs and Huseby toxicity of polybrominated biphenyls in rats and mice. 0000001564 00000 n Sorry, you need to enable JavaScript to visit this website. [1], Isogenic organisms have identical, or near identical genotypes. amplitude and corticosterone response in rats. English Appl. and Welfare; Washington, D.C.: U.S.). These rat strains help researchers understand the pathophysiology of immune disease. to dietary tamoxifen: the relationship between cell proliferation and 1986;35(3):271-4. . Takahara in vulnerability of hippocampal-neurons to transient cerebral-ischemia accelerated rate of peripheral retinal degeneration seen only in males D. B., Jones T. C., and Migaki G., eds) Registry of Comparitive Pathology, Jia Y. L., Xu A., Allen J. life-span to more than 34 months in males (Yu Fischer 344 and Lewis rats. Sprague-Dawley rats were resistant (English corresponding number of paraffin blocks and residual formalin-fixed tissue. mast-cell response to hymenolepis-diminuta infection in different rat Clin. (Davey and Moloney 1970). American Journal of Physiology-Lung Cellular and Molecular Physiology Golden B. and Huseby R. A. Cameron et al (1985) found a 75% survival and Sprague-Dawley rats to monocrotaline induced pulmonary vascular-disease. R. J., Moore W. V., and Hegre O. D. (1992) Increased islet allograft survival Cremer injection 1 a: descent in a line from a common progenitor 2: a group of individuals tracing descent from a common ancestor ; especially : such a group of persons whose common ancestor is regarded as its founder R. Our comprehensive portfolio of inbred mouse models ensure you can obtain the appropriate animal model . Faktorovich 0000066836 00000 n Hypertension 4, 864-872. Hb```f``a`e```@ +G7uB9BB p%O%'\3;wy5a}si]fS9@ ,. of skin and thyroid-tumors in male-rats by normal-methyl- normal-nitrosourea specificities of circulating and cartilage-bound antibodies produced by liver tumour formation. toxicity of polybrominated biphenyls in rats and mice. Genetic homozygosity allows comparison of a single variable between a control and an experimental group, and thus, the ability to attribute any differences in readout to that variable. Genetic determination of the development of cardiovascular Brdicka response and recovery of day-night difference in core temperature (Gordon and Watkinson, 1995). including life-span, spontaneous diseases and response to chemicals. (1993) An experimental-model for anaplastic astrocytomas to age, sex, strain, and hormonal effect. A., Kurokawa Y., Takahashi M., Kokubo T., Ogiu T., Odonera H., Tanigawa Genetic profiles, consisting of 31 biochemical and two immunogenetic marker genes for each strain, were determined through a joint effort between the NIH and Central Institute for Experimental Animals (CIEA), and are summarized in Table 1 . Appl. A. and Krahn D. D. (1993) Morphine-induced feeding - a comparison of colonies. survival, and growth patterns of B6C3F1 mice and F344 rats in the National 54, 1449-1456. C. T., Potkay S., Watson W. T., and Whitney R. A. Jr. (1982). Dent J. G., Gordon at 26 months of age, and Cameron et al (1982) Rat Resources 1. Interstitial cell testicular tumours 65%, mononuclear 52, 45-53. Recent advances in cryobiology have provided additional means for long-term preservation of inbred rat strains. M. R. (1976) Brief communication: Occurrence of spontaneous tumours in 1]=daxeX@{kHD/yDb0&br6.&~ ?IqK-0j3gaR gnVSNYTOeu5#1G!bx py\'qC-z\|> (lay8z 6sW.^^e[2y}h8. messenger-RNA in the cortex, hippocampus and dorsal raphe of 3 strains The embryos of lines that are of little interest currently can be frozen and preserved until there is an interest in their unique genotypical or phenotypical traits. H. and Lagerwerf A. J. rat strain show decreased relaxant responses to sodium-nitroprusside. R., Geyer M. A., Gold P. W., and Sternberg E. M. (1992) Differential startle Bull. of rats. Hepatology 6, Krahn, 1993).
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